Poster presentation not to be missed at ENA.
“Quantification of PI3K/AKT/mTOR pathway inhibition is predictive of biological response”
Date: Thursday, October 24
Session title: Biomarkers Assays
Poster#: PB196
By using InnoSIGN Comprehensive Pathway Analysis (CPA) it is possible to quantitatively measure the capacity of drugs to inhibit activity of the pathways (like PI3K) and to correlate its activity directly to biological response. Pathway activity measurement is more predictive for the cell growth inhibition than measurement of Ki-67 mRNA expression. The mechanism of action of drugs, including the efficacy on pathway inhibition, can be explored in more detail using CPA and might be used for optimal compound selection and patient stratification.
